Cefepime

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$$

Dosing

Adult

1-2g IV q8-12h

Restricted Use

Suspected or documented Pseudomonas aeruginosa infection and in the management of gram-negative meningitis.

General Information

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Drug Monitoring

Laboratory

  • CBC, CMP weekly

Clinical

  • Hypersensitivity

  • Diarrhea

  • Other GI effects

Adverse Effects

  • GI effects

  • Hypersensitivity reactions

  • C. difficile

Additional Information

Higher dosing may be required for cystic fibrosis and/or febrile neutropenia

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic