Ceftazidime-Avibactam

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$$$$

Dosing

Adult

2.5 g IV q8h

Renal

Adjust dose for CrCl <50 ml/min

Hepatic

No adjustment needed

Pediatric

Data is insufficient in the Pediatric population

Restricted Use

Infectious Diseases consult required for use.

Restricted per UCLA Policy HS 1444. Should be reserved for patients with little or no other treatment alternatives.

Reserved primarily for management of documented infections caused by CRE

General Information

Common Usage

In patients with documented CRE infection

Drug Monitoring

Laboratory

  • CBC, CMP weekly

Clinical

  • Monitor for changes in renal function

Adverse Effects

  • ¬†Diarrhea

  • ¬†Vomiting

  • Hypersensitivity reaction