Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$/$$

Dosing

Adult

Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

Renal

CrCl >50 mL/min

  • Uncomplicated: 1 g IV Q24h

  • Meningitis: 2 g IV Q12h

  • Endocarditis & Osteomyelitis: 2 g IV Q24h

CrCl <50 mL/min

  • No change

General Information

Common Usage

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

Empiric therapy of hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Empiric therapy of spontaneous bacterial peritonitis

Drug Monitoring

Laboratory

  • CBC, CMP weekly

  • Consider more frequent liver enzymes in patients with biliary disease

Clinical

  • Hypersensitivity

  • Diarrhea

  • Other GI effects

  • Signs of biliary sludge

  • Signs of gallstones

Adverse Effects

  • GI effects

  • Hypersensitivity reactions

  • C. difficile

  • Biliary sludging

  • Gallstones

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic