General Spectrum of Activity

Gram positive: Group A,B,C,G Streptococci, S. pneumoniae, viridans Streptococci.

Gram negative: Most Enterobacteriaceae, H. influenzae, M catarrhalis, Pasteurella spp.

Anaerobes: Prevotella melaninogenica, Clostridium (not C. difficile), Peptostreptococci.

Does not cover: Enterococci, B. fragilis, Pseudomonas and other more resistant gram negatives, ESBL or AmpC producing Enterobacteriaceae, Listeria, and not the agent of choice for staphylococcal infections.

Notes

  • Cefotaxime and Ceftriaxone have comparable activity against Enterobacteriaceae.