300-450mg IV q8h for usual indications
900mg IV q8h for necrotizing skin/soft tissue infections or toxic shock syndrome
300-450mg PO q6h
CrCl >50 mL/min
600 - 900 mg IV Q8h
300 - 450 mg PO Q8h
CrCl <50 mL/min
Consider dose reduction in hepatic insufficiency
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta-lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Muscle relaxants, e.g., atracurium, baclofen, diazepam.
St. Johns Wort
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor
CSF penetration: Poor