Fluconazole - Renal - Adult Dosing

Fluconazole has high oral bioavailability – consider initiating with/switching to oral therapy when patient tolerating orals

CrCl >50 mL/min

Oropharyngeal Candidiasis: 100mg daily
Esophageal Candidiasis: 200mg daily
Severe Infections : 400mg daily
Other: 100 - 400 mg IV/PO Q24h

CrCl 10 - 50 mL/min

50 - 200 mg IV/PO Q24h

CrCl <10 mL/min (ESRD not on HD)

50 -100 mg IV/PO Q24h

Dialysis (HD)

200 mg IV/PO daily

Dialysis (CRRT)

400 – 800 mg IV/PO Q24h