Antimicrobials
Fluconazole

Fluconazole

Low
Excellent
IV:$ PO Tablets:$ PO Suspension:$$

Spectrum of Activity

General Information

Candida infections both mucocutaneous and invasive - i.e. Candidemia

Cryptococcus and Coccidioides infections

Antifungal prophylaxis in immunocompromised

Laboratory

  • Baseline and periodic LFTs and Cr (dose adjustment assessment)

Clinical

  • GI effects
  • Prolongation of QT interval with risk factors
  • Hypersensitivity
  • Photosensitivity
  • Drug-drug interactions
  • GI effects
  • Hepatitis
  • QT prolongation
  • Hypersensitivity

Many via CYP450 - suggest review specific patient medications

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics

Risk when combining with other QTc prolonging medications

Antimicrobial class: Triazole antifungal. Decreases ergosterol synthesis.

Pregnancy category: C

Average serum half life: 20 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic