Gentamicin - Pediatric Dosing

Creatinine Clearance >50mL/min/1.73m²

Uncomplicated Infection
7 mg/kg/dose Q24H*

Cystic Fibrosis
10mg/kg/dose Q24H*

Hematology/Oncology
6mo - <9yrs: 10 mg/kg/dose Q24H*
9yrs - <12yrs: 8 mg/kg/dose Q24H*
>12yrs: 7 mg/kg/dose Q24H*

Creatinine Clearance 10-50mL/min/1.73m²

Uncomplicated Infection
CrCl 40-59: 7 mg/kg/dose Q36H
CrCl 20-39: 7 mg/kg/dose Q48H

Cystic Fibrosis
10mg/kg/dose Q36H*

Hematology/Oncology
6mo - <9yrs: 10 mg/kg/dose Q36H*
9yrs - <12yrs: 8 mg/kg/dose Q36H*
>12yrs: 7 mg/kg/dose Q36H*

Creatinine Clearance ≤10mL/min/1.73m²

Do not use extended interval dosing.
Call pharmacy.

Notes

*Check a gentamicin level 8H (6-14H) after start of infusion of first dose.

Dosing interval (q24H, q36H, or q48H) dependent upon Extended Interval Level and reference to the Extended Interval Dosing Nomogram

Note

Obtain Trough within 30 min before the next dose and Peak 30 min after 30 min infusion.
Goal Peak:
8-10 mcg/mL, synergy 3-4 mcg/mL.
Goal Trough:
<1 mcg/mL

Creatinine Clearance >50mL/min/1.73m²

Uncomplicated Infection
2.5mg/kg/dose Q8H

Cystic Fibrosis
3.3mg/kg/dose Q8H

Synergy
1mg/kg/dose Q8H

Creatinine Clearance 40-50mL/min/1.73m²

2.5mg/kg/dose Q12H

Creatinine Clearance 20-39mL/min/1.73m²

2.5mg/kg/dose Q24H

Creatinine Clearance <20mL/min/1.73m²

Loading dose, then monitor levels every 12-24 hours, target: level <1 mcg/mL

Creatinine Clearance ≤10mL/min/1.73m²

Loading dose, then monitor levels every 12-24 hours, target: level <1 mcg/mL