Levofloxacin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

IV:$
PO:$

Dosing

Adult

500-750mg PO/IV daily

General Information

Common Usage

Lower respiratory infection (CAP, HAP), intraabdominal infection

Drug Monitoring

Laboratory

  • Consider periodic Cr and LFTs with prolonged use

Clinical

  • Hypersensitivity

  • GI effects

  • Drug interactions (warfarin),

  • Prolongation of QT interval (amiodarone),

  • CNS effects,

  • Photosensitivity

Adverse Effects

  • GI effects

  • Arthropathy (especially in pediatric patients)

  • Tendon rupture

  • Prolongation of QT interval

  • CNS effects

Major Interactions

  • Other QTc prolonging agents

  • Divalent cations - decreased absorption

  • NSAIDs - increase seizure risk

  • Warfarin - increased INR

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic