Levofloxacin - Renal - Adult Dosing

Levofloxacin has high oral bioavailability – consider initiating with/switching to oral therapy when patient tolerating orals

CrCl >50 mL/min

250-500mg IV/PO Q24h

CrCl 10 - 50 mL/min

500mg x1 then 250mg IV/PO Q24h

CrCl <10 mL/min (ESRD not on HD)

500mg x1 then 250mg IV/PO Q48h

Dialysis (HD)

500mg x1 then 250mg Q48h

Dialysis (CRRT)

750mg x1 then 250mg-500mg Q24h

CrCl >50 mL/min

750mg IV/PO Q24h

CrCl 10 - 50 mL/min

750mg x1 then 750mg IV/PO Q48h

CrCl <10 mL/min (ESRD not on HD)

750mg x1 then 500mg IV/PO Q48h

Dialysis (HD)

500mg x1 then 250mg Q48h

Dialysis (CRRT)

750mg x1 then 250mg-500mg Q24h