Meropenem - Renal - Adult Dosing

CrCl >50 mL/min

2g IV Q8h

CrCl 25 - 50 mL/min

2g IV Q12h

CrCl 10-25 mL/min

1g IV Q12h

CrCl < 10 mL/min (ESRD not on HD)

1g IV Q24h

Dialysis (HD)

500mg IV x1 now then 500mg QPM

Give post HD on HD days

Dialysis (CRRT)

1g IV Q8-12h*

*Recommend 1g Q8h for CVVHD ultrafiltration rates exceeding 2L/hr

CrCl >50 mL/min

1 g IV Q8h

CrCl 25 - 50 mL/min

1g IV Q12h

CrCl 10-25 mL/min

0.5g IV Q12h

CrCl < 10 mL/min (ESRD not on HD)

0.5 g IV Q24h

Dialysis (HD)

500mg IV x1 now then 500mg QPM

Give post HD on HD days

Dialysis (CRRT)

1g IV Q8-12h*

*Recommend 1g Q8h for CVVHD ultrafiltration rates exceeding 2L/hr