Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

$$

Dosing

Adult

75mg PO BID x 5 days or longer in selected patients i.e. immunocompromised, critically ill

Prophylaxis dose 75mg PO daily

Renal

Adjust for CrCl < 60

General Information

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

Rare

  • ┬áStevens Johnson

Common

  • Nausea

  • Vomiting

Severe

  • Hypersensitivity

  • Neuropsychiatric

Additional Information

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID

Pharmacology

Antimicrobial class: Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic