Penicillin G - Renal - Adult Dosing

Except in the case of hemodialysis, administration should be as a continuous infusion over 24 hours

CrCl >50 mL/min

18-24 MU IV Q24h

CrCl 10 - 50 mL/min

8-16 MU IV Q24h

CrCl <10 mL/min (ESRD not on HD)

8-12 MU IV Q24h

Dialysis (HD)

8-12 MU IV Q24h

Dialysis (CRRT)

8-16 MU IV Q24h