Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$

Dosing

Adult

3.375 gm q8h (Extended 4-hr infusion)

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia

Drug Monitoring

Laboratory

  • CBC, CMP weekly

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Major Interactions

Incr. levels of methotrexate

Additional Information

Use with caution for CNS infections

Alternate dosing may be necessary for special populations, e.g. cystic fibrosis and morbid obesity

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic