Ethambutol
Pediatric

Pediatric

Once Daily Oral Therapy for TB

Note
  • ID CONSULT REQUIRED (HS1444)
  • Use as part of a multi-drug regimen.
  • Due to ever changing recommendations due to the emerging resistance profiles, please consult the CDC and WHO for the most up-to-date recommendations.
  • Reference: Official American Thoracic Society/Infectious Diseases Society of Americal/Center for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children https://doi.org/10.1093/cid/ciw694
  • Dosing based upon lean body weight
Infants, Children and Adolescents < 15 years and < 40kg

15 to 25 mg/kg/dose-PO Q24H

Infants, Children and Adolescents < 15 Years and > 40kg

Refer to adult dosing

Adolescents > 15 years

Refer to adult dosing

Renal

Note

Dosing adjustment not clearly established in pediatrics. Ethambutol is primarily renally eliminated and based upon available pharmacokinetic/pharmacodynamic data in adults, dose adjustment is warranted. The following recommendations are based upon the ADULT ATS/CDC/IDSA recommendations (2016) and only serve as a guideline

CrCl < 30 mL/min

20-25 mg/kg/dose three times weekly. Do not administer daily dosing.

Hemodialysis

20 to 25 mg/kg/dose three times weekly. Given after dialysis on dialysis days.

Peritoneal Dialysis

Administer every 48 hours

Continuous Renal Replacement Therapy (CRRT)

Administer dose every 24H to 36H

Hepatic

No adjustments