5 mg/kg/dose (usual dose: 300 mg) once daily
Altnerate options available, including 3 times weekly therapy.
Please consult ID
CrCl >50 mL/min
CrCl <50 mL/min or Dialysis
There are no dosage adjustments; however, use with caution, may accumulate and additional liver damage may occur in patients with preexisting liver disease.
Contraindicated in patients with acute liver disease or previous isoniazid-associated hepatic injury.
Treatment with isoniazid for latent tuberculosis infection should be deferred in patients with acute hepatic diseases.
Nontuberculous mycobacterium (M. kansasii)
LFTs in patients with underlying liver disease or comorbidities
For ALT or AST >3 times the ULN: discontinue or temporarily withhold treatment.
>10%: Hepatic: Increased serum transaminases (mild and transient 10% to 20%)
Multiple CYP Interactions