Once-Daily Therapy 5 mg/kg/dose (usual dose: 300 mg) once daily Altnerate options available, including 3 times weekly therapy. Please consult ID
There are no dosage adjustments; however, use with caution, may accumulate and additional liver damage may occur in patients with preexisting liver disease.
Contraindicated in patients with acute liver disease or previous isoniazid-associated hepatic injury.
Treatment with isoniazid for latent tuberculosis infection should be deferred in patients with acute hepatic diseases.
CrCl <50 mL/min or Dialysis
CrCl >50 mL/min
Nontuberculous mycobacterium (M. kansasii)
LFTs in patients with underlying liver disease or comorbidities
For ALT or AST >3 times the ULN: discontinue or temporarily withhold treatment.
>10%: Hepatic: Increased serum transaminases (mild and transient 10% to 20%)
Multiple CYP Interactions