Cefpodoxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

$$

Dosing

Adult

200mg PO Q12H

Renal

CrCl<30 mL/minute

  • Administer Q24H

General Information

Common Usage

  •  Chronic bronchitis (acute exacerbation)

  •  Otitis media (acute)

  •  Pharyngitis/tonsillitis

  •  Pneumonia (community-acquired)

  •  Sinusitis (acute maxillary)

  •  Skin and skin structure infections (uncomplicated)

  •  Urinary tract infections (uncomplicated)

Drug Monitoring

Laboratory

  • Renal function

Clinical

  • Hypersensitivity

  • Diarrhea

  • Other GI effects

Adverse Effects

  • GI effects - diarrhea, nausea, abdominal pain

  • Hypersensitivity reactions

  • C. difficile

Pharmacology

Antimicrobial class: Third generation cephalosporin - oral

Pregnancy category: B

Average serum half life: 2-3 hours

Biliary penetration: Moderate/good (early studies)

CSF penetration: Poor

Lung penetration: Moderate

Urine penetration: Therapeutic