Dicloxacillin

C. diff Risk

Medium

Oral Bioavailability

Low

Approximate Cost

$

Dosing

250mg - 500 mg PO Q6H

No specific dose adjustment provided by the manufacturer

No specific dose adjustment provided by the manufacturer

General Information

Common Usage

Treatment of MSSA infections

Drug Monitoring

Clinical

  • Baseline and periodic CBC with differential

  • Periodic comprehensive metabolic panel (especially with prolonged therapy)

Adverse Effects

  • Allergy (immediate or delayed)

  • Phlebitis at injection site in a peripheral vein

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Major Interactions

  • Can increase methotrexate levels

  • Tetracyclines can diminish dicloxacillin activity

  • Warfarin: decreased PT/INR with concommitant dicloxacillin

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 0.7 hours

Biliary penetration: Moderate

Urine penetration: Therapeutic

Lung penetration: Therapeutic