Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$

Dosing

Adult

250-500mg PO q6-8h

Renal

Excretion prolonged in renal impairment

General Information

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (e.g. upper respiratory tract)

Prophylaxis after rheumatic fever

Drug Monitoring

Laboratory

  •  Periodic CBC, SCr

Clinical

  •  Monitor for allergy

Adverse Effects

  •  Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  •  Serum sickness

  •  AIN

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic