Vancomycin PO

C. diff Risk

Low

Oral Bioavailability

None

Approximate Cost

Capsules:$$
Suspension:$

Dosing

Adult

125 mg PO/NG/OG q6h for 10-14 days

Intra-colonic dose 500 mg in 100mL of NS by rectal enema q6h

Life-threatening infection or ileus: 500 mg PO/NG/OG q6h

General Information

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent disease

Drug Monitoring

Laboratory

  • ┬áPossibility of accumulation in severe renal dysfunction.

  • ┬áConsider checking a vancomycin level in dialysis patients

Additional Information

No oral absorption.

May increase vancomycin resistant enterococci colonization in the gut.

Pharmacology

Antimicrobial class: Glycopeptide

Pregnancy category: B

Average serum half life: 0 hours

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None