Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Ceftolozane-Tazobactam

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$$$$

Spectrum of Activity

General Spectrum of Activity

General Spectrum of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Adult

1.5 - 3 g IV Q8H

Renal

Renal - Adult

Hepatic

Hepatic - Adult

No dose adjustment

Pediatric

Pediatric

Data is insufficient in the Pediatric population

Restricted Use

Restricted Use

Infectious Diseases consult required for use.

Should be reserved for patients with little or no other treatment alternatives.

Reserved primarily for management of documented infections caused by CRE

General Information

Common Usage

Common Usage

In patients with documented multi-drug resistant (MDR) pseudomonas or CRE organisms

Drug Monitoring

Drug Monitoring

Laboratory

  • CBC, CMP weekly

Adverse Effects

Adverse Effects

  •  GI intolerance

  •  Headache

Pharmacology

Pharmacology

Antimicrobial class: Cephalosporin Combination

Pregnancy category: B