Loading Dose 20000 to 25000 IU/kg IV x 1 Maintenance Dose 250000 to 30000 IU/kg/day in 2 divided doses starting 12 hours after loading dose
No dose adjustment
Infectious Diseases consultation required
Infections due to MDR Enterobactericiae, Acinetobacter, and Pseudomonas on a case-by-case bass.
Per UCLA Policy HS 1444, formal ID consultation is required for use of polymyxin B
Infections due to non-MDR pathogens for which alternate therapy, particularly beta-lactam antibiotics, are available
Severe infectious caused by multidrug-resistant Gram-negative organisms when other antimicrobial options are limited
May enhance the effect of other neuromuscular blocking agents