Clostridium perfringens

Precautions

Standard Precautions

General Information

Alternate Treatment

  • Clindamycin

  • Metronidazole

  • Piperacillin/tazobactam

  • Ertapenem

Pathogen information

Anaerobic spore forming gram positive bacilli, box-car shaped

Epidemiology

Environmental (soil, water) organism as well as human/animal digestive tract.

Associated with penetrating wounds with environmental exposure

Associated syndromes

  • ¬†Gas gangrene/Clostridial myonecrosis

  • ¬†Necrotizing skin and soft tissue infection

  • Septic abortion

  • Intra-abdominal abscess

  • Fatal bacteremia with massive exotoxin-mediated hemolysis

  • Foodborne self-limited gastrointestinal illness

Additional Information

Surgical debridement of devitalized tissue crucial

IVIG and hyperbaric oxygen may be considered but lack of rigorous studies to support routine use