Recurrent MRSA Skin Infections

Topical Decolonization

Consider if a patient has ≥ 2 episodes per year or other household members develop infection


Mupirocin applied intranasally BID for 5 days may be considered in patients with documented evidence of MRSA nasal colonization

Mupirocin therapy should be initiated after resolution of acute infection

Mupirocin is not recommended for patients without documented MRSA nasal colonization


Bathing or showering with chlorhexidine (Hibiclens) or dilute bleach baths every other day for 1 week then twice weekly

Patients should be instructed not to get these substances into ears, eyes, or other mucous membranes

Systemic Antibiotics

Systemic antibiotics are NOT recommended solely for decolonization