Single positive cultures of CoNS should NOT be treated unless they are confirmed by follow-up cultures, the patient is immunosuppressed and/or critically ill, or the patient has implanted hardware such as prosthetic valves or a cardiac device (e.g. pacemaker). In these cases, treatment can be started but repeat cultures should be sent PRIOR to initiation of therapy to confirm the diagnosis.
Vancomycin (Dosing per pharmacy)
Oxacillin 12g/24h if susceptible. Preferred to vancomycin
5-7 days if catheter removed (preferred)
10-14 days if catheter salvage attempted