Typical cases of cellulitis in patients without systemic signs/symptoms of infection should include antimicrobial treatment targeting streptococci, particularly Group A streptococci
Other streptococcal species may also be present.
Cellulitis associated with penetrating trauma, MRSA infection elsewhere, IV drug use, SIRS, oral antibiotic failure, etc.
Antimicrobials targeting BOTH streptococci and MRSA are indicated.
The following regimens include coverage for MSSA, community-acquired MRSA (CAMRSA), and streptococci.
Coverage for Gram negative organisms is unnecessary except in very specific patient populations (see “Other causes” link below).
For mild non-purulent cellulitis, cephalexin monotherapy is likely sufficient.
Furuncles, Carbuncles, “Boils”
Other causes of cellulitis in select patient populations