Neutropenic Fever

Use This Guideline For

Management of Neutropenic Fever in adults

Management of Fever and Hematopoietic Stem Cell Transplant (HSCT) in adults


Neutropenic fever can be highly complex with subtle signs/symptoms of infection. Consider Infectious Diseases consultation in all patients with febrile neutropenia, especially if source cannot be found or patient is febrile for >72 hours.

  • Fever: Temp >38.0C ax or oral (no rectal temps if neutropenic)

  • Neutropenia: ANC <500

Routine ED Antibiotics

  • Administer within 60 min of arrival.

  • Doses need to be adjusted in patients with moderate to severe renal failure.