Only those patients with conditions associated with the highest risk for adverse outcomes from IE should receive prophylaxis.
Prosthetic cardiac valves (both bioprosthetic and mechanical)
Previous infective endocarditis
Congenital heart disease (CHD) only for the following specific conditions:
Unrepaired cyanotic CHD, including palliative shunts and conduits.
Completely repaired congenital heart defect with prosthetic material or a prosthetic device placed either during surgery or by catheter intervention, during the first 6 months after the procedure
CHD repair with residual defects at the site or adjacent to the site of a prosthetic patch or prosthetic device
Development of cardiac valvulopathy after cardiac transplantation