Administer a single dose 30-60 minutes before procedure
If the antibiotic is inadvertently not administered before the procedure, it may be administered up to 2 hours after the procedure
For patients with a history of anaphylaxis to a penicillin, a structurally dissimilar R1 side chain cephalosporin can be administered without testing or additional precautions
If a patient is already receiving long-term antibiotic therapy with an antibiotic that is also recommended for IE prophylaxis, an antibiotic from a different class should be used