Data suggest that monotherapy is sufficient for the treatment of most Gram-negative infections.
The use of 2 agents to treat proven or suspected Gram-negative infections should be limited to the following situations:
The second agent should be an aminoglycoside in most cases. Fluoroquinolone resistance is common among Gram-negative organisms at UCLA.
Double beta-lactam combinations (e.g. zosyn + meropenem) should be avoided.