Amoxicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$0.50/day

Dosing

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

PO 20-30 mg/kg/DAY divided q12h

Low dose: PO 40-50 mg/kg/DAY divided q8h
High dose: PO 80-90 mg/kg/DAY divided q8h. High dose can be divided q12h for otitis media.
Max 4 g/DAY.

General Information

Common Usage

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and Urinary tract infection

Adverse Effects

Allergy/rash (immediate or delayed), cytopenias.

EBV related rash (not allergy).

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life: Neonates, full-term: 3.7 hours. Infants and children: 1 to 2 hours

Route of Elimination: Renal excretion (60% unchanged drug)