Amoxicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$0.50/day

Dosing

Low dose: PO 40-50 mg/kg/DAY divided q8h
High dose: PO 80-90 mg/kg/DAY divided q8h. High dose can be divided q12h for otitis media.
Max 4 g/DAY.

PO 20-30 mg/kg/DAY divided q12h

General Information

Common Usage

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections. Commonly used for upper respiratory infections and Urinary tract infection

Adverse Effects

Allergy/rash (immediate or delayed), cytopenias. EBV related rash (not allergy).

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life: Neonates, full-term: 3.7 hours. Infants and children: 1 to 2 hours

Route of Elimination: Renal excretion (60% unchanged drug)