For high dose, to keep clavulanic acid dose < 12.5 mg/kg/DAY, 14:1 formulation (90mg/kg/DAY) can be achieved by combining 45mg/kg/DAY of 7:1 formulation & 45mg/kg/DAY of plain amoxicillin.
Max daily dose of amoxicillin is 4g/day
Max daily dose of clavulanate is 12.5 mg/kg/day.
High dose: PO 80-90 mg/kg/DAY divided q12h
PO Low dose: 40-50 mg/kg/DAY divided q8h
Dosing based on amoxicillin component.
PO 30 mg amoxicillin/kg/DAY divided q12h
Use with caution. Use contraindicated in patients with a history of amoxicillin and clavulanate-associated hepatic dysfunction.
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Prophylaxis/treatment of bite wounds
Polymicrobial infections of the respiratory tract or abdomen
Skin and soft tissue infections
For prolonged therapy, monitor liver enzymes and function
Hepatotoxicity due to clavulinate is usually mild, liver failure is rare. EBV related rash (not allergy).
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Average serum half life: Adults: ~1 hour. Amoxicillin pharmacokinetics are not affected by clavulanic acid
Route of Elimination: Urine (amoxicillin 50% to 70% unchanged drug; clavulanic acid 25% to 40% unchanged drug)