10mg/kg/DAY given as a single daily dose, Max: 500mg/DAY.
Administer IV for at least 2 days then switch to oral.
Pharyngitis: 12 mg/kg/dose (max: 500mg/dose) once daily x 5 days
PO: 10mg/kg/DAY given as a single dailyt dose on day 1 (max: 500mg/dose), then 5mg/kg/DAY given as a single daily dose on days 2-5 (max: 250mg/dose)
Oral: 10-20mg/kg/DAY given as a single daily dose.
IV: 10mg/kg.DAY given as a single daily dose
Use with caution in hepatic impairment.
Dose adjustment not necessary. Use with caution if CrCl<10mL/minute.
Community acquired pneumonia, Pertussis, upper respiratory tract infections, Chlamidial infections, mycobacterial infections, Mycobacterium avium complex (MAC) prophylaxis in HIV patients
Monitor QTc in patients with increased risk.
Prolongation of QTc interval.
While less risk of interaction compared to other macrolides, several potential CYP450 interactions may occur; consult a pharmacist for for more details.
Avoid concurrent use with other drugs that prolong QTc
Antimicrobial class: Macrolide
Average serum half life: pediatrics: 54.5 hours
Route of Elimination: 50% excreted unchanged in bile.
6-14% excreted unchanged in urine.