Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
IV, IM 50–100mg/kg/DAY divided q8h.
IV, IM 100-150mg/kg/DAY divided q8h.
Skin and soft tissue infection (i.e. cellulitis).
Susceptible Staphylococcal, Streptococcal and Gram negative infections.
Allergy (immediate or delayed).
Can cause positive Coombs, cytopenias.
Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin
Antimicrobial class: 1st Generation Cephalosporin
Average serum half life: Neonates: 3-5 hours
Adults: 1.8 hours
Route of Elimination: excreted unchanged in urine