Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Max: 2g/dose, 12g/day
Meningitis: IV/IM 200-300mg/kg/DAY divided q6h
IV/IM 100-200mg/kg/DAY divided q6-8h
Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection including SBP, musculoskeletal i.e. septic arthritis, and urinary tract infection.
Rash, localized phlebitis at injection site, allergy.
Positive Coombs test, neutropenia, diarrhea.
Preferred cephalosporin in neonates.
Outside of the neonatal period, cefotaxime may be automatically substituted by AHS pharmacy to ceftriaxone unless "no substitution" is specified.
Antimicrobial class: 3rd Generation Cephalosporin
Average serum half life:
neonates: 3.4-4.6 hours.
children: 1.5 hours
Route of Elimination: urine: ~60% as unchanged drug and metabolites in urine