Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Cystic Fibrosis: IV 150-200mg/kg/DAY (up to 400mg/kg/DAY) divided q6-8h
IV/IM 100-150mg/kg/DAY divided q8h.
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins
Allergy (immediate and delayed)- note potential cross-reactivity with aztreonam based on side chain
Antimicrobial class: 3rd generation Cephalosporin
Average serum half life:
neonates <23 days: 2.2-4.7 hours
adults: 1-2 hours
Route of Elimination: by glomerular filtration with 80-90% of dose excreted as unchanged drug in urine within 24 hours.