If patient has renal and hepatic impairment, do not exceed doses of 2g/day
Cefotaxime is preferred in neonates.If necessary, ceftriaxone can be given at a dose of 50 mg/kg q24h.
IV,IM: 50-75mg/kg/DAY given as a single daily dose. Max: 4g/day.
IV, IM: 100mg/kg/DAY divided q12-24h.
(Give q12h for meningitis & CNS infection)
Empiric therapy of bacterial meningitis
Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)
Allergy/rash (immediate or delayed).
Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
Calcium containing IV solutions bind to ceftriaxone forming an insoluble precipitate- avoid concurrent use with calcium contaning colutions in neonates.
IM ceftriaxone may be given with 1% lidocaine to minimize pain at injection site
Antimicrobial class: Parenteral Cephalosporin - 3rd Generation
Average serum half life:
Neonates: 1-4 days: 16 hours; 9-30 days: 9 hours
Route of Elimination: unchanged in the urine (33-67%) by glomerular filtration and in feces via bile.