Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$3/day

Dosing

IV, IM: 100mg/kg/DAY divided q12-24h.
(Give q12h for meningitis & CNS infection)
Max: 4g/day.

IV,IM: 50-75mg/kg/DAY given as a single daily dose. Max: 4g/day.

Cefotaxime is preferred in neonates.If necessary, ceftriaxone can be given at a dose of 50 mg/kg q24h.

If patient has renal and hepatic impairment, do not exceed doses of 2g/day

General Information

Common Usage

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

Adverse Effects

  • Allergy/rash (immediate or delayed).

  • Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities

  • Pseudocholelithiasis.

Major Interactions

Calcium containing IV solutions bind to ceftriaxone forming an insoluble precipitate- avoid concurrent use with calcium contaning colutions in neonates.

Additional Information

IM ceftriaxone may be given with 1% lidocaine to minimize pain at injection site

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Average serum half life:

  • Neonates: 1-4 days: 16 hours; 9-30 days: 9 hours

  • Pediatrics: 4.1-6.6h

Route of Elimination: unchanged in the urine (33-67%) by glomerular filtration and in feces via bile.