Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

$10/day

Dosing

PO 50-150mg/kg/DAY divided q6h. Max: 6g/DAY

IV/IM 100-200mg/kg/DAY divided q4-6h. Max: 12g/DAY.

Give oral dose on empty stomach. Oral liquid is not palatable. Consider oral cephalexin as alternative.

General Information

Common Usage

Treatment of sensitive MSSA and CoNS infections

Drug Monitoring

Renal and hepatic function, CBC with differential, diarrhea

Adverse Effects

  • allergy (immediate or delayed)

  • phlebitis (IV)

  • cytopenias

  • eosinophilia

  • interstitial nephritis

  • abnormal liver enzymes

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Average serum half life: Adults:0.5-1.5 h (prolonged in renal impairment and in neonates)

Route of Elimination: urine and feces