Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

$10/day

Dosing

Give oral dose on empty stomach. Oral liquid is not palatable. Consider oral cephalexin as alternative.

PO 50-150mg/kg/DAY divided q6h. Max: 6g/DAY

IV/IM 100-200mg/kg/DAY divided q4-6h. Max: 12g/DAY.

General Information

Common Usage

Treatment of sensitive MSSA and CoNS infections

Drug Monitoring

Renal and hepatic function, CBC with differential, diarrhea

Adverse Effects

  • allergy (immediate or delayed)

  • phlebitis (IV)

  • cytopenias

  • eosinophilia

  • interstitial nephritis

  • abnormal liver enzymes

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Average serum half life: Adults:0.5-1.5 h (prolonged in renal impairment and in neonates)

Route of Elimination: urine and feces