Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
3-6 mg/kg/DAY given as a single daily dose
Up to 12 mg/kg/DAY given as a single daily dose for serious infections and candidemia
Daily dose of fluconazole is the same for oral and IV administration unless otherwise specified.
Candida infections both mucocutaneous and invasive - i.e. Candidemia
Cryptococcus and Coccidioides infections
Antifungal prophylaxis in immunocompromised
Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement
Hepatic enzyme abnormalities
Many via CYP450 - suggest review interactions with pharmacist.
Risk when combining with other QTc prolonging medications
Antimicrobial class: Triazole antifungal
Average serum half life:
Premature neonates: 47-73.6 hours.
Pediatrics (9 months to 15 years): oral 19.5-25 hours
5- 15 years: IV 15-18 hours
Adults: Normal renal function: ~30 hours
Route of Elimination: 80% unchanged in urine; 11% metabolites in urine.