250,000 to 400,000 units/kg/DAY divided q4h. Max 24 million units/DAY.
100,000 to 250,000 units/kg/DAY divided q6h. Max 8 million units/DAY.
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Therapy of Streptococcal and other documented susceptible infections, syphilis
renal and hepatic function, CBC with differential, hypersensitivity reactions and IV site for phlebitis.
Allergy/rash (immediate or delayed), seizures, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes, serum sickness
Antimicrobial class: penicillin
Average serum half life: Neonates: <6 days: 3.2 to 3.4 hours. 7 to 13 days: 1.2 to 2.2 hours. >14 days: 0.9 to 1.9 hours.
Pediatrics: 0.5-1.2 hours.
Adults normal renal function: 30- 50 mintes
Route of Elimination: Renal (58% to 85% unchanged drug)