25-40 mg/kg/24h IV divided q6-8h
Maximum: 900 mg/dose
20-30 mg/kg/24h PO divided q6-8h
Maximum: 1.8 g/24h
150-450 mg PO q6-8h
600-900 mg IV q8h
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin and soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Diarrhea -if severe diarrhea, consider C.diff infection
Allergy (immediate & delayed)
GI upset, diarrhea, pseudomembranous colitis
Abnormal liver enzymes
Some preparations of Clindamycin injection contain benzyl alcohol, which has caused gasping syndrome in neonates.
Antimicrobial class: Lincosamide
Average serum half life:
Premature neonates: 8.7 hours
Full term neonates: 3.6 hours.
Infants 1 month to 1 year: 3 hours.
Children and Adults: 2-3 hours
Route of Elimination: Mostly hepatic metabolism. 10% of an oral dose excreted in urine and 3.6% excreted in feces as active drug and metabolites.