75-150mg/kg/24h IV divided q8h
Cystic Fibrosis: 200mg/kg/24h IV (up to 400mg/kg/24hIV ) divided q6-8h
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities. Notable lack of gram positive activity versus other cephalosporins
Allergy (immediate and delayed)
Antimicrobial class: 3rd generation Cephalosporin
Route of Elimination: by glomerular filtration with 80-90% of dose excreted as unchanged drug in urine within 24 hours.
Average serum half life:
neonates <23 days: 2.2-4.7 hours
adults: 1-2 hours