75-150mg/kg/24h IV divided q8h
Cystic Fibrosis: 200mg/kg/24h IV (up to 400mg/kg/24hIV ) divided q6-8h
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Broad gram negative coverage including Pseudomonas, generally used for febrile neutropenia, or other infections based on susceptibilities. Notable lack of gram positive activity versus other cephalosporins
Allergy (immediate and delayed)
Antimicrobial class: 3rd generation Cephalosporin
Average serum half life:
neonates <23 days: 2.2-4.7 hours
adults: 1-2 hours
Route of Elimination: by glomerular filtration with 80-90% of dose excreted as unchanged drug in urine within 24 hours.