Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$5/day

Dosing

Adult

1-2 g IV q8h
(may need higher dosing i.e. 3 g in obesity)

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

  • Skin and soft tissue infection (i.e. cellulitis).

  • Surgical prophylaxis.

  • Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Adverse Effects

  • Allergy (immediate or delayed). Cross allergenicty unlikely with other B-lactams

  • Can cause positive Coombs, cytopenias

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin for the treatment of cellulitis

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Route of Elimination: excreted unchanged in urine

Average serum half life: Neonates: 3-5 hours
Adults: 1.8 hours