Fungicidal therapy of yeast/fungus/mould infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity
Serum electrolytes (K, Mg)
CBC with differential.
Infusion related symptoms: fever/rigors/nausea/vomiting/headache
Electrolyte abnormalities - hypoKalemia and hypoMagnesemia, loss of bicarbonate
Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy.
Amphotericin B deoxycholate (conventional) is the preparation of choice in neonates.
Premedicate with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms.
Antimicrobial class: Antifungal - polyene
Average serum half life:
Premature neonates (GA: 27.4 ± 5 weeks): 14.8 hours (range: 5 to 82 hours)
Infants and Children (4 months to 14 years): 18.1 ± 6.6 hours (range: 11.9 to 40.3 hours)
Route of Elimination: Urine (2% to 5% unchanged); ~40% eliminated over 7-day period and may be detected in urine for up to 8 weeks after discontinued use