Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection
Creatine kinase weekly, renal function
Myopathy including rhabdomyolysis, GI side effects common, rash, phlebitis, increased INR
Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy)
Recommend Infectious Disease Consult
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection
Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane
Average serum half life: Neonates and Infants <3 months: 6.2 hours. Children: 5 to 7 hours
Route of Elimination: 78% of the dose excreted in urine as unchanged drug; feces (6%)