3-5 mg/kg/24h IV q24h
Refer to Amphotericin B deoxycholate (conventional) for neonatal dosing (preferred form in neonates)
5 mg/kg/dose IV q24h
Contact pharmacy for more information regarding use in renal impairment.
Fungicidal therapy of yeast/fungus/mould infection (not for use in urinary tract infection)
Invasive candidiasis, aspergillosis, cryptococcosis
Serum electrolytes (K, Mg)
CBC with differential
Infusion related symptoms: fever/rigors/nausea/vomiitng/headache
Electrolyte abnormalities - hypokalemia and hypomagnesemia, loss of bicarbonate
Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy.
Lipid formulations of AmB (Ambisome, Abelcet) are NOT interchangable
Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)
Route of Elimination: Effects of hepatic and renal impairment on drug disposition are unknown
Average serum half life:
No pediatric data.
Liposomal: Adults: 100-153 hours (terminal half life)