Cefotaxime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$30/day

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection (with metronidazole), and urinary tract infection

Adverse Effects

  • Rash

  • Localized phlebitis at injection site

  • Allergy

  • Positive Coombs test

  • Neutropenia

  • Diarrhea

Additional Information

Preferred cephalosporin in neonates

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin

Route of Elimination: urine: ~60% as unchanged drug and metabolites in urine

Average serum half life:

  • Neonates: 3.4-4.6 hours

  • Children: 1.5 hours