Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

IV-15$

Dosing

General Pediatric

50-150 mg/kg/24h IV divided q8h
Maximum: 6 g/24h

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Community acquired lower respiratory tract infections.

Adverse Effects

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • GI upset, diarrhea

  • Abnormal liver enzymes

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Route of Elimination: 66-100% as unchanged drug in urine by both glomerular filtration and tubular secretion

Average serum half life: Pediatrics: 1.4-1.9 hours.