15 mg/kg/24h PO divided q12h
Maximum: 1 g/24h
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Second line for community aquired pneumonia (drug of choice if atypical), URTI, H. pylori, and mycobacterial infections
Monitor QTc in patients with increased risk
GI upset, diarrhea
Prolongation of QTc interval
Substrate of CYP3A4. Multiple CYP450 interactions possible - consult a pharmacist for more detail. May increase digoxin, carbamazepine level. Caution with QTc prolonging medications
Concentration: 25 mg/mL
Not all strengths of oral liquids are listed nor are available on IWK formulary
250 mg tablet
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.
Antimicrobial class: Macrolide
Average serum half life: Adult: Clarithromycin: 3-7 hours
14-OH-clarithromycin (active metabolite): 5-9 hours
Route of Elimination: Urine (20-40% as unchanged drug, additional 10%-15% as active metabolite); feces (29% to 40% mostly as metabolites)