Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Therapy for herpes virus infections (HSV and VZV) including encephalitis
Prophylaxis of herpes virus infections if recurrent disease or immunocompromised
Follow creatinine, urea, urine output as appropriate, liver enzymes and CBC.
BUN/Creatinine and fluid balance must be monitored daily in patients receiving high dose acyclovir. Ensure adequate hydration during and for at least 2 hours following administration. Manufacturer suggests 1 litre of fluid/24 hours/gram of acyclovir and recommends a minimum urine output of 500 mL/24 hours/gram of acyclovir.
Liver or renal dysfunction
Crystal nephropathy (keep patient well hydrated)
Antimicrobial class: Antiviral, nucleoside analogue
Route of Elimination: Primarily kidney with 60-90% of drug excreted unchanged in the urine
Average serum half life: Neonates: 4 hours
Children 1-12 years: 2-3 hours