60 mg/kg/24h IV divided q8h X 21 days
30-45 mg/kg/24h IV divided q8h X 21 days
(doses as high as 60 mg/kg/24h IV divided q8h may be used but are associated with a higher incidence of nephrotoxicity)
30 mg/kg/24h IV divided q8h X 21 days
15-30 mg/kg/24h IV divided q8h x 5-7 days (duration up to 14 days if immunocompromised)
Use lower dose if immunocompetent, use higher dose if immunocompromised.
80 mg/kg/24h PO divided in 3-4 doses x 5-7 days (duration up to 14 days if immunocompromised)
Maximum: PO 800 mg /24h (200 mg q6h) if mild to moderate and PO 1.6 grams /24h (400 mg q6h) if severe.
For chronic suppression for recurrent episodes in immunocompetent patients; some experts recommend 20mg/kg/dose PO every 8-12 hours for 6 to 12 months, then re-evaluate need.
Maximum: PO 400mg/dose.
30 mg/kg/24h IV divided q8h
Doses as high as 45mg/kg/24h IV can be used in immunocompromised, disseminated or CNS disease.
80 mg/kg/24h PO divided q6h
Maximum: 3.2 grams/24h OR 800 mg/dose